We’re proud to announce a new special issue on Trained Immunity in Neuroscience: Immune Memory in Brain Health and Disease. This special issue aims to provide a platform for advancing research on the role of trained immunity within the central nervous system and its impact on neurological disorders.

Recent evidence shows that the brain exhibits dynamic immune responses during injury, infection, and neurodegeneration. Trained immunity, defined as the long-term functional reprogramming of innate immune cells, is increasingly recognized as a key mechanism linking neuroinflammation to disease progression. This includes the role of microglia and peripheral immune cells in shaping central nervous system pathology.

This special issue will focus on molecular, epigenetic, and metabolic mechanisms underlying innate immune memory in conditions such as ischemic brain injury, neurodegenerative diseases, neuroinfections, and brain tumors. Topics of interest include immune cell reprogramming, neuroinflammation, disease progression, and translational or clinical implications.

The goal of this special issue is to provide state-of-the-art research on neuro-trained immunity and its implications for diagnosis, prognosis, and treatment. We invite researchers to submit original research articles, reviews, short communications, and clinical or computational studies. There is no restriction on manuscript length, but full experimental and methodological details must be provided where applicable.

Find out more about the special issue here.