VLDL in Atherosclerosis: Variety of Mechanistic Implications

Abstract

Very-Low-Density Lipoprotein (VLDL) particles play a pivotal role as precursors for Intermediate-Density Lipoprotein (IDL) and eventually transform into Low-Density Lipoprotein (LDL). These particles have been categorized based on size and particle charge. Various types of VLDL impact diverse physiological processes in the human body. The accumulation of VLDL, along with other triglyceride-rich lipoproteins, significantly contributes to the development of atherosclerotic lesions, plaque rupture, progression of liver disorders such as hepatitis and Non-Alcoholic Fatty Liver Disease (NAFLD) and other conditions including obesity, insulin resistance and coronary artery disease. This review delves into the potential of VLDL in averting atherosclerosis and seeks to identify its therapeutic applications. Special emphasis is placed on exploring the role of VLDL in atherosclerosis, understanding its atherogenic properties and utilizing VLDL as a predictive marker for pathological conditions. The study design focuses on examining the data on pathways through which VLDL could be leveraged as a therapeutic target and preventive measure against cardiovascular diseases.