Placebo-Driven Clinical Trials of Transfer Point Glucan #300 in Children with Chronic Respiratory Problems: Antibody Production
- 1 University of Louisville, United States
- 2 Regional Institute of Public Health, Ústí nad Labem, Czech Republic
- 3 Sanatorium Edel, Zlaté Hory, Czech Republic
Abstract
The role of glucan in stimulation of immune reactions has been well-established. In this report, we focused on the antibody production in glucan-supplemented children with chronic respiratory problems. We measured the levels of salivary IgA, IgM and IgG in 40 children aged 8-12 years and evaluated the effects of 100 mg d-1 oral dose of glucan. We found a significant increase in production of all tested antibodies in the glucan-stimulated group, but a decrease of antibody production in the control group. A thirty-day oral application of yeast-based natural immunomodulator β-glucan strongly stimulated the mucosal immunity of children with chronic respiratory problems.
DOI: https://doi.org/10.3844/ajisp.2013.43.47
Copyright: © 2013 Vetvicka Vaclav, Richter Josef, Svozil Vladimir, Rajnohova Dobiasova Lucie and Kral Vlastimil. This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Glucan
- Children
- Mucosal Immunity
- IgA
- IgM
- IgG