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Frequency: Quarterly
ISSN: 1553-6203 (Print)
ISSN: 1558-6340 (Online)
Research Article Open Access

Correlation of IFN-Inducible Protein 10 Levels in Sera with Disease Severity and Clinical Outcome of the Dengue Patients

Ying-Ray Lee1, Nguyen-Thanh Hung2, Ching-Chuan Liu3, Kao-Jean Huang3, Huan-Yao Lei3, Yee-Shin Lin3, Jen-Reng Wang3, Trai-Ming Yeh3, Shun-Hua Chen3 and Hsiao-Sheng Liu3
  • 1 Institute of Basic Medical Sciences, Vietnam
  • 2 Children’s Hospital No. 1, Ho Chi Minh City, Vietnam
  • 3 National Cheng Kung University, Taiwan

Abstract

Dengue Virus (DV) infection may cause life-threatening Dengue Hemorrhagic Fever (DHF) and Dengue Shock Syndrome (DSS). Although many cytokines involved in the pathogenesis of DHF/DSS have been reported, the expression status of IFN-inducible protein-10 (IP-10) in dengue patients is still unknown. This is the first report to unravel that IP-10 level was significantly elevated in the sera of Dengue Fever (DF) patients. However, the level declined while the disease proceeds to severe DHF/DSS, which is different from the expression profiles of other DV related cytokines in the patients. IP-10 may be used to monitor the severity of dengue disease.

American Journal of Infectious Diseases
Volume 4 No. 1, 2008, 18-21

DOI: https://doi.org/10.3844/ajidsp.2008.18.21

Submitted On: 9 August 2007 Published On: 31 March 2008

How to Cite: Lee, Y., Hung, N., Liu, C., Huang, K., Lei, H., Lin, Y., Wang, J., Yeh, T., Chen, S. & Liu, H. (2008). Correlation of IFN-Inducible Protein 10 Levels in Sera with Disease Severity and Clinical Outcome of the Dengue Patients. American Journal of Infectious Diseases, 4(1), 18-21. https://doi.org/10.3844/ajidsp.2008.18.21

Open AccessCopyright: © 2008 Ying-Ray Lee, Nguyen-Thanh Hung, Ching-Chuan Liu, Kao-Jean Huang, Huan-Yao Lei, Yee-Shin Lin, Jen-Reng Wang, Trai-Ming Yeh, Shun-Hua Chen and Hsiao-Sheng Liu. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Keywords

  • IP-10
  • dengue virus