Evaluation of Anti-Inflammatory Potential of Turmimax® an in vivo and in vitro Study
- 1 Research and Development, Star Hi Herbs Pvt Ltd, Jigani, Bangalore, Karnataka, India
Abstract
The main objective of this study was to investigate the in vivo and in vitro anti-inflammatory effects of the Turmimax® bio-enhanced turmeric formulation. By comparing the relative fluorescence intensities of the interleukins IL-8 (Interleukin-8) and IL-12 (Interleukin-12) cytokines in stimulated murine Raw 264.7 macrophages, Turmimax® was evaluated for its anti-inflammatory in vitro efficacy. Turmimax® was administered orally in two doses, 100 and 200 mg/kg, to assess its in vivo anti-inflammatory potential in ear edema induced by croton oil in mice and paw edema induced by histamine in albino rats. Diclofenac sodium 10 mg/kg p.o. is the standard drug. The results demonstrated that Turmimax® significantly and dose-dependently decreased the production of the inflammatory mediator’s interleukin-8 and IL-12. According to the current investigation results, Turmimax® has shown strong anti-inflammatory effects.
DOI: https://doi.org/10.3844/ajbbsp.2022.386.393
Copyright: © 2022 Firoz Hussain H M., Nanjundaiah S., Sadashiva Channangihalli Thimmegowda, Neethumol Benny and Rashmi Y.. This is an open access article distributed under the terms of the
Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
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Keywords
- Turmimax®
- Raw 264.7 Cell Line
- IL-8 and IL-12
- Flow Cytometry and Anti-Inflammatory Activity